Transient Splenial Lesions in the Splenium of Corpus Callosum in Seven Patients: MR Findings and Clinical Correlations

Transient reversible lesions (TSL) in the splenium of corpus callosum are often found on MR imaging, with the patients recovering without any neurologic defects after mild clinical courses (1). MR imaging have shown restricted diffusion in the central portion of splenium of corpus callosum (2). Many studies have presented the causing factors of TSL, defining hypothetic pathogenesis. These lesions are well documented to be associated with antiepileptic drugs (3-8). The pathophysiology of TSL has been hypothesized in many studies (1, 6, 9-11). According to these studies, the main possible pathophysiology is the rapid resolution of intramyelinic edema or the influx of INTRODUCTION www.ksmrm.org JKSMRM 17(1) : 1-7, 2013